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clip170  (Addgene inc)


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    Structured Review

    Addgene inc clip170
    OligoMT designed for real-time visualization of the microtubule cytoskeleton. (a) Schematic illustrating the fusion of the N-terminal MT-binding region (aa 131–350) of <t>CLIP170</t> with the p73 oligomerization domain of (OD; aa 351–399) to enable MT binding. CAP-GLY, cytoskeleton-associated protein glycine-rich; MT, microtubule; and OD, oligomerization domain. (b) Confocal images showing the distribution of the mCherry (mCh)-tagged MT-binding region of CLIP170 (aa 131–350) and OligoMT (p73 351–399 -CLIP170 131–350 chimera) in HeLa cells. The bar graph on the right shows the F MT / F cytosol ratios in HeLa cells expressing oligomerization domains from the p53 family fused to CLIP170 131–350 ( n = 30 cells; mean ± SEM). (c) Confocal images of HeLa cells transfected with mCh-OligoMT (red) and costained with an anti-α-tubulin antibody (green) and DAPI (blue). The red and green fluorescence intensities across the dashed line were plotted alongside the images to illustrate the extent of signal overlap. (d) Time-lapse confocal images depict cell mitosis in HeLa cells expressing H2B-GFP (green) and mCh-OligoMT (red). The bottom panel displays the differential interference contrast (DIC) views of the assayed cells. HeLa cells expressing mCh-OligoMT exhibited mitotic progression comparable to the control group (also, see Supporting Video S2 ), indicative of its minimal perturbation to host cells. Scale bar, 5 μm.
    Clip170, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/clip170/product/Addgene inc
    Average 93 stars, based on 9 article reviews
    clip170 - by Bioz Stars, 2026-04
    93/100 stars

    Images

    1) Product Images from "Genetically Encoded Microtubule Binders for Single-Cell Interrogation of Cytoskeleton Dynamics and Protein Activity"

    Article Title: Genetically Encoded Microtubule Binders for Single-Cell Interrogation of Cytoskeleton Dynamics and Protein Activity

    Journal: ACS Sensors

    doi: 10.1021/acssensors.4c01167

    OligoMT designed for real-time visualization of the microtubule cytoskeleton. (a) Schematic illustrating the fusion of the N-terminal MT-binding region (aa 131–350) of CLIP170 with the p73 oligomerization domain of (OD; aa 351–399) to enable MT binding. CAP-GLY, cytoskeleton-associated protein glycine-rich; MT, microtubule; and OD, oligomerization domain. (b) Confocal images showing the distribution of the mCherry (mCh)-tagged MT-binding region of CLIP170 (aa 131–350) and OligoMT (p73 351–399 -CLIP170 131–350 chimera) in HeLa cells. The bar graph on the right shows the F MT / F cytosol ratios in HeLa cells expressing oligomerization domains from the p53 family fused to CLIP170 131–350 ( n = 30 cells; mean ± SEM). (c) Confocal images of HeLa cells transfected with mCh-OligoMT (red) and costained with an anti-α-tubulin antibody (green) and DAPI (blue). The red and green fluorescence intensities across the dashed line were plotted alongside the images to illustrate the extent of signal overlap. (d) Time-lapse confocal images depict cell mitosis in HeLa cells expressing H2B-GFP (green) and mCh-OligoMT (red). The bottom panel displays the differential interference contrast (DIC) views of the assayed cells. HeLa cells expressing mCh-OligoMT exhibited mitotic progression comparable to the control group (also, see Supporting Video S2 ), indicative of its minimal perturbation to host cells. Scale bar, 5 μm.
    Figure Legend Snippet: OligoMT designed for real-time visualization of the microtubule cytoskeleton. (a) Schematic illustrating the fusion of the N-terminal MT-binding region (aa 131–350) of CLIP170 with the p73 oligomerization domain of (OD; aa 351–399) to enable MT binding. CAP-GLY, cytoskeleton-associated protein glycine-rich; MT, microtubule; and OD, oligomerization domain. (b) Confocal images showing the distribution of the mCherry (mCh)-tagged MT-binding region of CLIP170 (aa 131–350) and OligoMT (p73 351–399 -CLIP170 131–350 chimera) in HeLa cells. The bar graph on the right shows the F MT / F cytosol ratios in HeLa cells expressing oligomerization domains from the p53 family fused to CLIP170 131–350 ( n = 30 cells; mean ± SEM). (c) Confocal images of HeLa cells transfected with mCh-OligoMT (red) and costained with an anti-α-tubulin antibody (green) and DAPI (blue). The red and green fluorescence intensities across the dashed line were plotted alongside the images to illustrate the extent of signal overlap. (d) Time-lapse confocal images depict cell mitosis in HeLa cells expressing H2B-GFP (green) and mCh-OligoMT (red). The bottom panel displays the differential interference contrast (DIC) views of the assayed cells. HeLa cells expressing mCh-OligoMT exhibited mitotic progression comparable to the control group (also, see Supporting Video S2 ), indicative of its minimal perturbation to host cells. Scale bar, 5 μm.

    Techniques Used: Binding Assay, Expressing, Transfection, Fluorescence, Control



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    Image Search Results


    OligoMT designed for real-time visualization of the microtubule cytoskeleton. (a) Schematic illustrating the fusion of the N-terminal MT-binding region (aa 131–350) of CLIP170 with the p73 oligomerization domain of (OD; aa 351–399) to enable MT binding. CAP-GLY, cytoskeleton-associated protein glycine-rich; MT, microtubule; and OD, oligomerization domain. (b) Confocal images showing the distribution of the mCherry (mCh)-tagged MT-binding region of CLIP170 (aa 131–350) and OligoMT (p73 351–399 -CLIP170 131–350 chimera) in HeLa cells. The bar graph on the right shows the F MT / F cytosol ratios in HeLa cells expressing oligomerization domains from the p53 family fused to CLIP170 131–350 ( n = 30 cells; mean ± SEM). (c) Confocal images of HeLa cells transfected with mCh-OligoMT (red) and costained with an anti-α-tubulin antibody (green) and DAPI (blue). The red and green fluorescence intensities across the dashed line were plotted alongside the images to illustrate the extent of signal overlap. (d) Time-lapse confocal images depict cell mitosis in HeLa cells expressing H2B-GFP (green) and mCh-OligoMT (red). The bottom panel displays the differential interference contrast (DIC) views of the assayed cells. HeLa cells expressing mCh-OligoMT exhibited mitotic progression comparable to the control group (also, see Supporting Video S2 ), indicative of its minimal perturbation to host cells. Scale bar, 5 μm.

    Journal: ACS Sensors

    Article Title: Genetically Encoded Microtubule Binders for Single-Cell Interrogation of Cytoskeleton Dynamics and Protein Activity

    doi: 10.1021/acssensors.4c01167

    Figure Lengend Snippet: OligoMT designed for real-time visualization of the microtubule cytoskeleton. (a) Schematic illustrating the fusion of the N-terminal MT-binding region (aa 131–350) of CLIP170 with the p73 oligomerization domain of (OD; aa 351–399) to enable MT binding. CAP-GLY, cytoskeleton-associated protein glycine-rich; MT, microtubule; and OD, oligomerization domain. (b) Confocal images showing the distribution of the mCherry (mCh)-tagged MT-binding region of CLIP170 (aa 131–350) and OligoMT (p73 351–399 -CLIP170 131–350 chimera) in HeLa cells. The bar graph on the right shows the F MT / F cytosol ratios in HeLa cells expressing oligomerization domains from the p53 family fused to CLIP170 131–350 ( n = 30 cells; mean ± SEM). (c) Confocal images of HeLa cells transfected with mCh-OligoMT (red) and costained with an anti-α-tubulin antibody (green) and DAPI (blue). The red and green fluorescence intensities across the dashed line were plotted alongside the images to illustrate the extent of signal overlap. (d) Time-lapse confocal images depict cell mitosis in HeLa cells expressing H2B-GFP (green) and mCh-OligoMT (red). The bottom panel displays the differential interference contrast (DIC) views of the assayed cells. HeLa cells expressing mCh-OligoMT exhibited mitotic progression comparable to the control group (also, see Supporting Video S2 ), indicative of its minimal perturbation to host cells. Scale bar, 5 μm.

    Article Snippet: pGFP-EB1 (Addgene no. 17234), CLIP170 (no. 54044), and MDM2-YFP (no. 53962) were purchased from Addgene.

    Techniques: Binding Assay, Expressing, Transfection, Fluorescence, Control